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ALK Gene Fusion Detection Probe
1.Fleetness: Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.
2.Accuracy: Less non-specific background staining (dyeing). Increase difficult samples detection rate.
3.Reproducibility: Different laboratories test results are highly reproducible.
ALK gene break apart probe uses orange labeled dye ALK gene (3 ' End) 2p23.2 region, and a green dye ALK gene (5' End) to mark 2p23.1-p23.2 region. ALK gene break apart probe can detect all ALK gene rearrangement, avoiding missed diagnosis caused by a single fusion gene (such as EML4-ALK).
l Rodig SJ, et al. (2009) Clin Cancer Res 15: 5216-23.
l Sasaki T, et al. (2010) Eur J Cancer 46: 1773-80.
l Von Laffert M, et al. (2013) Lung Cancer 81: 200-6.
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